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Beyer, Eric C.

One or more keywords matched the following items that are connected to Beyer, Eric C.

Item Type	Name
Concept	HeLa Cells
Academic Article	Heterotypic docking of Cx43 and Cx45 connexons blocks fast voltage gating of Cx43.
Academic Article	Gap junction channels formed by coexpressed connexin40 and connexin43.
Academic Article	Connexin43 and connexin45 form heteromeric gap junction channels in which individual components determine permeability and regulation.
Academic Article	Cardiac gap junction channels show quantitative differences in selectivity.
Academic Article	Loss of function and impaired degradation of a cataract-associated mutant connexin50.
Academic Article	A carboxyl terminal domain of connexin43 is critical for gap junction plaque formation but not for homo- or hetero-oligomerization.
Academic Article	N-terminal residues in Cx43 and Cx40 determine physiological properties of gap junction channels, but do not influence heteromeric assembly with each other or with Cx26.
Academic Article	A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts.
Academic Article	The cytoplasmic accumulations of the cataract-associated mutant, Connexin50P88S, are long-lived and form in the endoplasmic reticulum.
Academic Article	Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cells.
Academic Article	The GJA8 allele encoding CX50I247M is a rare polymorphism, not a cataract-causing mutation.
Academic Article	A novel GJA8 mutation is associated with autosomal dominant lamellar pulverulent cataract: further evidence for gap junction dysfunction in human cataract.
Academic Article	The N terminus of connexin37 contains an alpha-helix that is required for channel function.
Academic Article	Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50.
Academic Article	An intact connexin N-terminus is required for function but not gap junction formation.
Academic Article	Different domains are critical for oligomerization compatibility of different connexins.
Academic Article	Cx30.2 can form heteromeric gap junction channels with other cardiac connexins.
Academic Article	A mutant connexin50 with enhanced hemichannel function leads to cell death.
Academic Article	Autophagy: a pathway that contributes to connexin degradation.
Academic Article	Atomic force microscopy of Connexin40 gap junction hemichannels reveals calcium-dependent three-dimensional molecular topography and open-closed conformations of both the extracellular and cytoplasmic faces.
Academic Article	Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function.
Academic Article	Cataracts are caused by alterations of a critical N-terminal positive charge in connexin50.
Academic Article	Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins.
Academic Article	An aberrant sequence in a connexin46 mutant underlies congenital cataracts.
Academic Article	A connexin50 mutant, CX50fs, that causes cataracts is unstable, but is rescued by a proteasomal inhibitor.
Academic Article	Atrial fibrillation-associated connexin40 mutants make hemichannels and synergistically form gap junction channels with novel properties.
Academic Article	The connexin46 mutant, Cx46T19M, causes loss of gap junction function and alters hemi-channel gating.
Academic Article	Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses.
Academic Article	Characterization of a variant of gap junction protein a8 identified in a family with hereditary cataract.
Academic Article	Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation.

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HeLa Cells